EFFECT OF LONG-TERM WARFARIN THERAPY ON THROMBIN-ACTIVATABLE INHIBITOR OF INHIBITOR BY PATIENTS WITH PERSISTENT ATRIAL FIBRILLATION

Rubanenko Anatoly Olegovich, Postgraduate student, Samara State Medical University, neron@samtel.ru
Shchukin Yuriy Vladimirovich, Doctor of medical sciences, professor, vice-rector for educational and social development, head of sub-department of propedutic therapy, Samara State Medical University, samgmu_pt@mail.ru
Germanov Andrey Vladimirovich, Candidate of medical sciences, associate professor, head of department of cardiology, Samara State Medical University, rean1mator2323@rambler.ru

616.12-008.313.2:615.273.53:616-005.1-08

The authors have studied the influence of long term warfarin therapy on thrombin activated fibrinolysis inhibitor (TAFI) and left atrial appendage (LAA) thrombosis in patients with coronary heart disease (CHD) and permanent form of atrial fibrillation (AF). Long term warfarin therapy results in significant decrease in intravascular activation of blood coagulation and promotes blood clot lysis in LAA in some cases. The possibility of reducing the concentration of TAFI by warfarin therapy requires further confirmation in larger studies.

atrial fibrillation, thrombin activated fibrinolysis inhibitor, coagulation, warfarin.